Publications

Publications from our lab

2021

• • Nagesh Y. Kadam©, Sukanta Behera^U, Sandeep Kumar, Anindya Ghosh-Roy and Kavita Babu© (2021); The G-protein coupled receptor SRX-97 is required for concentration dependent sensing of benzaldehyde in Caenorhabditis elegans. eNeuro 2021 Jan 04; 8(01):ENEURO.0011-20.2020. https://www.eneuro.org/content/8/1/ENEURO.0011-20.2020.long

bioRxiv Preprint: https://www.biorxiv.org/content/10.1101/2020.01.04.894824v1.

This work was highlighted by the DBT/Wellcome Trust India Alliance website at https://www.indiaalliance.org/news/how-animals-smell

• • Pratima Pandey*©, Anuradha Singh*, Harjot Kaur, Anindya Ghosh-Roy and Kavita Babu© (2021); Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans. PLoS Genetics 2021 Feb 01; 17(2):e1009346. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009346

bioRxiv Preprint: https://www.biorxiv.org/content/10.1101/779405v1.

This work was highlighted through a write-up by Preethi Ravi at the DBT/Wellcome Trust India Alliance website https://www.indiaalliance.org/news/when-worms-went-tipsy

The first authors talk about their work to Biopatrika at

https://biopatrika.com/2021/03/19/interview-ethanol-sedative-behaviors-caenorhabditis-elegans/

• • Pratima Pandey©, Umer S. Bhat, Anuradha Singh, Aiswarya Joy^U, Varun Birari^U, Nagesh Y. Kadam and Kavita Babu© (2021); Dauer formation in C. elegans is modulated through AWC and ASI dependent chemosensation. eNeuro 2021 Apr 14; 8(02):ENEURO.0473-20.2021. https://www.eneuro.org/content/8/2/ENEURO.0473-20.2021.long

• • Anuradha Singh, Kavita Babu© and Pratima Pandey© (2021); Ethanol Induced Sedative Behavior: An assay to investigate increased dopamine signaling in C. elegans (protocol). Bio-protocol 2021 Jul 05; 11(13). https://bio-protocol.org/e4083

• • Umer S. Bhat*, Navneet Shahi*, Siju Surendran* and Kavita Babu© (2021); Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs (invited article for the research topic "Regulation of Synaptic Structure and Function"). Front. Mol. Neurosci. 2021 Dec 02; 14:786471. https://www.frontiersin.org/articles/10.3389/fnmol.2021.786471/full

2020

• • Ashwani Bhardwaj*, Pratima Pandey* and Kavita Babu© (2020); Control of locomotory behavior of Caenorhabditis elegans by the immunoglobulin superfamily protein RIG-3. Genetics 2020 Jan 01; 214(1): 135-45. https://www.genetics.org/content/214/1/135

• • Kavita Babu© (2020); Sticking and signalling at the synapse: two sides of the same coin? Resonance 2020 Mar; 25(3): 419-29. https://www.ias.ac.in/article/fulltext/reso/025/03/0419-0429 This was an invited pedagogical piece for a special issue of Resonance on Women in Science.

• • Umer S. Bhat© and Kavita Babu© (2020); Neuropeptides: the slower neurotransmitters. Resonance 2020 Dec; 25(12): 1741-52. https://www.ias.ac.in/article/fulltext/reso/025/12/1741-1752. This was a pedagogical piece.

2019

• • Yogesh Dahiya©, Saloni Rose^U, Shruti Thapliyal, Shivam Bhardwaj^U, Maruthi Prasad^U and Kavita Babu© (2019); Differential regulation of innate and learned behavior by CREB1/CRH-1 in Caenorhabditis elegans. The Journal of Neuroscience 2019 Oct 2; 39(40): 7934-46. https://www.jneurosci.org/content/39/40/7934.long

bioRxiv Preprint: https://www.biorxiv.org/content/early/2019/01/04/508986.

• • Shruti Thapliyal© and Kavita Babu© (2019); C. elegans Locomotion: Finding Balance in Imbalance (invited review for the special edition of a Springer book). Advances in Experimental Medicine and Biology 2019 Jan 13; 1112: 185-96. https://link.springer.com/chapter/10.1007%2F978-981-13-3065-0_14

• • Kavita Babu© and Sandhya P Koushika© (2019); Sydney Brenner (1927-2019). Current Science 2019 Jun 25; 16(12): 2106-09. https://www.currentscience.ac.in/Volumes/116/12/2106.pdf

• • Vina Tikiyani© and Kavita Babu©(2019); Claudins in the brain: Unconventional functions in neurons. Traffic 2019 Nov 01; 20(11): 807-14. https://onlinelibrary.wiley.com/doi/10.1111/tra.12685

2018

• • Shruti Thapliyal, Amruta Vasudevan*, Yongming Dong*, Jihong Bai, Sandhya P. Koushika and Kavita Babu© (2018); The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction. PLoS Genetics 2018 Mar; 14(3): e1007236. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007263

• • Shruti Thapliyal, Shruthi Ravindranath^U and Kavita Babu© (2018); Regulation of glutamate signaling in the sensorimotor circuit by CASY-1A/Calsyntenin in Caenorhabditis elegans. Genetics 2018 Apr 01; 208(4): 1553-64. http://www.genetics.org/content/208/4/1553.long

• • Ashwani Bhardwaj*, Saurabh Thapliyal*^U, Yogesh Dahiya and Kavita Babu© (2018); FLP-18 functions through the G-protein coupled receptors NPR-1 and NPR-4 to modulate reversal length in Caenorhabditis elegans. The Journal of Neuroscience 2018 May 16; 38(20): 4641-54. http://www.jneurosci.org/content/38/20/4641.long

Mentioned on This week in the journal by Teresa Esch. The Journal of Neuroscience 2018 May 16; 38(20) i.

Press Release from The Journal of Neuroscience for this work:

https://www.eurekalert.org/pub_releases/2018-04/sfn-buh042418.php

https://phys.org/news/2018-04-neuropeptide-roundworms-movement.html

• • Pallavi Sharma*, Lei Li*, Haowen Liu, Vina Tikiyani, Zhitao Hu© and Kavita Babu© (2018); The Claudin-like protein, HPO-30, is required to maintain LAChRs at the Caenorhabditis elegans neuromuscular junction. The Journal of Neuroscience 2018 Aug 08; 38(32): 7072-87. http://www.jneurosci.org/content/38/32/7072.long

• • Vina Tikiyani, Lei Li, Pallavi Sharma, Haowen Liu, Zhitao Hu and Kavita Babu© (2018); Wnt secretion is regulated by the tetraspan protein HIC-1 through its interaction with Neurabin/NAB-1. Cell Reports 2018 Nov 13; 25(7): 1856-71. https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31642-5

• • Raunaq Deo*, Manish S. Kushwah*, Sukrut C. Kamerkar, Nagesh Y. Kadam, Srishti Dar, Kavita Babu, Anand Srivastava and Thomas J. Pucadyil© (2018); ATP-dependent membrane remodeling links EHD1 functions to endocytic recycling. Nature Communications 2018 Dec 5; 9(1): 5187. https://www.nature.com/articles/s41467-018-07586-z

• • Shruti Thapliyal and Kavita Babu© (2018); Pentylenetetrazole (PTZ)-induced Convulsion Assay to Determine GABAergic Defects in Caenorhabditis elegans (invited protocol). Bio-protocol 2018 Sep 05; 8(17). https://bio-protocol.org/e2989

2017

• • Pratima Pandey, Ashwani Bhardwaj and Kavita Babu© (2017); Regulation of WNT Signaling at the Neuromuscular Junction by the Immunoglobulin Super-Family Protein RIG-3 in Caenorhabditis elegans . Genetics 2017 Jul 01; 206(3): 1521 -34. http://www.genetics.org/content/206/3/1521.long

Key

* — Equal contribution, © — Corresponding author/s, and u— Undergraduate student

Prior Publications

Dr. Kavita Babu

• Babu, K., Hu, Z., Chien, S-C., Garriga, G. and Kaplan, J.M. (2011) The Immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling. Neuron Jul 14; 71(1):103-16.†

• Hu, Z.*, Pym, E.C.G.*, Babu, K.*, Vahlishan Murray, A.B.* and Kaplan, J.M. (2011) A neuropeptide-mediated stretch response links muscle contraction to changes in pre-synaptic release of neurotransmitter. Neuron Jul 14; 71(1):92-102.†

• Babu, K.©, Bahri, S., Alphey, L. and Chia, W. (2005) Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila. Dev Biol Dec 15; 288(2): 372-86.†

• Babu, K., Cai, Y., Bahri, S., Yang, X. and Chia, W. (2004) Roles of Bifocal, Homer and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes. Genes Dev. Jan 15; 18(2): 138-43.†

• Helps, N.R.*, Cohen, P.T., Bahri, S.M., Chia, W. and Babu, K.* (2001) Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye. Mol Cell Biol. Mar: 21(6): 2154-64.†

Dr. Pratima Sharma Pandey

• Pandey, P. and Dhillon, H. S. (2012) The Caenorhabditis elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14, a G-alpha-i subunit. J Molecular Signaling Dec 5; 8(1): 13.†

• Pandey, P., Pierpont, T. and Dhillon, H. S. (2010) An alternatively spliced version of dop-2, a D2-like receptor gene. The Worm Breeders Gazette 18 (2):25.†

• Howard, R. A., Sharma, P., Hajjar, C., Caldwell, K. A., Caldwell, G. A., du Breuil, R., Moore, R. and Boyd, L. (2007) Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. BMC Cell Biol. July 30; 8(32).†

• Sharma, P. and Mondal A.K. (2006) Evidence that the MAPK-docking site in MAPKK Dpbs2p is essential for its function. Biochem Biophys Res Commun. July 28; 346(2):562-6.†

• Sharma, P. and Mondal, A.K. (2005). Evidence that C-terminal non-kinase domain of Pbs2p has a role in high osmolarity-induced nuclear localization of Hog1p. Biochem Biophys Res Commun. Mar 25; 328(4):906-13.†

• Sharma, P., Meena, N., Aggarwal, M. and Mondal, A.K. (2005). Debaryomyces hansenii, a highly osmo-tolerant and halo-tolerant yeast, maintains activated Dhog1p in the cytoplasm during its growth under severe osmotic stress. Current Genetics Sep; 48(3):162-70. †

• Bansal, P. K.*, Sharma, P.*, and Mondal, A.K. (2001). A PBS2 homologue from Debaryomyces hansenii shows differential effect on calcoflour and polymyxin B sensitivity in Saccharomyces cerevisiae. Yeast. Oct; 18:1207-1216.†

• Bansal, P. K., Sharma, P., and Mondal, A.K. (2001). A minisatellite sequence in the upstream region of the DURA3 gene from the halotolerant yeast Debaryomyces hansenii. Yeast. Sep 30; 18(13):1301-1307.†

Dr. Yogesh Dahiya

• Pandey, R. K., Sodhi, A., Biswas, S.K., Dahiya, Y., Dhillon, M.K. (2012) Mycobacterium indicus pranii mediates macrophage activation through TLR2 and NOD2 in a MyD88 dependent manner. Vaccine Aug; 30(39):5748-5754.†

• Pandey, R. K., Dahiya, Y., Sodhi, A. (2012) Mycobacterium indicus pranii downregulates MMP-9 and iNOS through COX-2 dependent and TNF-α independent pathway in mouse peritoneal macrophages in vitro. Microbes Infect. Apr; 14(4):348-356.†

• Dahiya, Y., Pandey, R. K., Sodhi, A. (2011) Nod2 downregulates TLR2/1 mediated IL1β gene expression in mouse peritoneal macrophages. PLoS One. 6(11):e27828.†

• Pandey, R. K., Bhatt, K. H., Dahiya, Y., Sodhi, A. (2011) Mycobacterium indicus pranii supernatant induces apoptotic cell death in mouse peritoneal macrophages in vitro. PLoS One. Feb; 6(2):e17093.†

• Dahiya, Y., Pandey, R. K., Bhatt, K. H., Sodhi, A. (2010). Role of prostaglandin E2 in peptidoglycan mediated iNOS expression in mouse peritoneal macrophages in vitro. FEBS Letters Oct 8; 584(19):4227-4232.†

• Bhatt, K. H., Pandey, R. K., Dahiya, Y., Sodhi, A. (2010). Protein kinase C delta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. Molecular Immunology Jan; 47(4):861-870.†

Dr. Vandita Bhat

• Rivera-Tarazona, L. K., Bhat, V. D., Kim, H., Campbell, Z. T., Ware, T. H. (2020). Shape-morphing living composites. Science Advances Jan 17; 6(3):eaax8582.†

• Qiu, C.*, Bhat, V. D.*, Rajeev, S., Zhang, C., Laslet, A. E., Wine, R. N., Campbell, Z. T., Tanaka Hall, T. M. (2019). A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity. eLife Aug 9; 8:e48968.†

• Bhat, V. D.*, McCann, K. L.*, Wang, Y., Fonseca, D. R., Shukla, T., Alexander, J. C., Qiu, C., Wickens, M., Lo, T. W., Tanaka Hall, T. M., Campbell, Z. T. (2019). Engineering a conserved RNA regulatory protein repurposes its biological function in vivo. eLife Jan 17; 8:e43788.†

• Zhou, Q., Kunder, N., De la Paz, J. A., Lasley, A. E., Bhat, V. D., Morcos, F., Campbell, Z. T. (2018). Global pairwise RNA interaction landscapes reveal core features of protein recognition. Nature Communications Jun 28; 9(1):2511.†

• Barragán-Iglesias, P., Lou, T. F., Bhat, V. D., Megat, S., Burton, M. D., Price, T. J., Campbell, Z. T. (2018). Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice. Nature Communications Jan 2; 9(1):10.†

Ashwani Bhardwaj

• Guleria, S., Tiku, A. K., Singh, G., Vyas, D., Bhardwaj, A. (2011) Antioxidant Activity and Protective Effect Against Plasmid DNA Strand Scission of Leaf, Bark, and Heartwood Extracts from Acacia catechu. J Food Sci. Sep; 76(7):C959-964.†

Navneet Shahi

• Balasubramanian, N., Sagarkar, S., Jadhav, M., Shahi, N., Sirmaur, R., Sakharkar, A. J. (2020) Role for histone deacetylation in traumatic brain injury-induced deficits in neuropeptide Y in arcuate nucleus: Possible implications in feeding behaviour. Neuroendocrinology.†

Key

† — Publication prior to joining the Babu lab